Daily rhythms drive dynamism in sleep, oscillations and interneuron firing, while excitatory firing remains stable across 24 h.

ABSTRACT: The adaptation to the daily 24-h light-dark cycle is ubiquitous across animal species and is crucial for maintaining fitness. This free-running cycle occurs innately within multiple bodily systems, such as endogenous circadian rhythms in clock-gene expression and synaptic plasticity. These phenomena are well studied; however, it is unknown if and how the 24-h clock affects electrophysiologic network function in vivo. The hippocampus is a region of interest for long timescale (>8 h) studies because it is critical for cognitive function and exhibits time-of-day effects in learning. We recorded single cell spiking activity and local field potentials (LFPs) in mouse hippocampus across the 24-h (12:12-h light/dark) cycle to quantify how electrophysiological network function is modulated across

SUBMITTER: Ognjanovski N 

PROVIDER: S-EPMC11664907 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature