Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells.

ABSTRACT: MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-specific miRNA that is predominantly expressed in the liver and plays an important role in liver metabolism and development. Dysregulation of miR-122 expression is associated with several liver-related diseases, including hepatocellular carcinoma and drug-induced liver injury (DILI). Given the potential of miR-122 as a biomarker, its effective detection is important for accurate diagnosis. However, miRNA detection methods still face challenges, particularly in terms of accurately identifying miRNA isoforms that may differ by only a single base. Here, wit

SUBMITTER: Robles-Remacho A 

PROVIDER: S-EPMC11665063 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature