DEMETER DNA demethylase reshapes the global DNA methylation landscape and controls cell identity transition during plant regeneration.

ABSTRACT:

Background

Plants possess a high potential for somatic cell reprogramming, enabling the transition from differentiated tissue to pluripotent callus, followed by the formation of de novo shoots during plant regeneration. Despite extensive studies on the molecular network and key genetic factors involved in this process, the underlying epigenetic landscape remains incompletely understood.

Results

Here, we explored the dynamics of the methylome and transcriptome during the two-step plant regeneration process. During the leaf-to-callus transition in Arabidopsis Ler, CG methylation shifted across genic regions, exhibiting a similar number of differentially methylated regions (DMRs) for both hypo- and hypermethylation. Pericentromeric regions underwent substantial CG and extensive

SUBMITTER: Lee S 

PROVIDER: S-EPMC11665089 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature