Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice.

ABSTRACT:

Background

Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasmatic nucleus (SCN) as the master clock, which is essential for driving rhythms in food intake and energy metabolism through neuronal projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN).

Results

We showed that chronic SD-induced aberrant expressions of AgRP/NPY and POMC attributed to compromised JAK/STAT3 signals and reduced energy expenditure in the mice, which can be rescued with AAV-genetic overexpression of BMAL1 into SCN. The potential mechanism may be related to

SUBMITTER: Du T 

PROVIDER: S-EPMC11665105 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature