Multi-locus investigation of Anopheles-mediated selective pressure on Plasmodium falciparum in Africa.

ABSTRACT:

Background

The high burden of malaria in Africa is largely due to the presence of competent and adapted Anopheles vector species. With invasive Anopheles stephensi implicated in malaria outbreaks in Africa, understanding the genomic basis of vector-parasite compatibility is essential for assessing the risk of future outbreaks due to this mosquito. Vector compatibility with P. falciparum arises from ancient coevolution and involves genes such as Pfs47 in P. falciparum and P47Rec in Anopheles. Questions remain about whether sub-continental vector variation is a selective pressure on current Plasmodium populations.

Methods

We analyzed the genetic diversity in parasite-vector interaction genes in P. falciparum and An. gambiae from 9 and 15 countries in Africa, respectively. Spec

SUBMITTER: Gunarathna I 

PROVIDER: S-EPMC11665118 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature