A shielded cascade of targeted nanocarriers spanning multiple microenvironmental barriers for inflammatory disease therapy.

ABSTRACT:

Background

The multi-biological barriers present in the inflammatory microenvironment severely limit the targeted aggregation of anti-inflammatory drugs in the lesion area. However, conventional responsive drug carriers inevitably come into contact with several pro-responsive stimulatory mediators simultaneously, leading to premature drug release and loss of most therapeutic effects. Breaking through the multi-level barriers of the inflammatory microenvironment is essential to improve the enrichment and bioavailability of drugs.

Results

In this study, we propose a novel two-stage structural strategy to build shielded cascades of targeted nanocarriers (FA-PTP@Que) through inflammatory mediators, using cascade structures to cross multiple environmental barriers. The cascade st

SUBMITTER: Liu F 

PROVIDER: S-EPMC11665124 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature