Mll4 in skeletal muscle fibers maintains muscle stem cells.

ABSTRACT:

Background

Muscle stem cells (MuSCs) undergo numerous state transitions throughout life, which are critical for supporting normal muscle growth and regeneration. Epigenetic modifications in skeletal muscle play a significant role in influencing the niche and cellular states of MuSCs. Mixed-lineage leukemia 4 (Mll4) is a histone methyltransferase critical for activating the transcription of various target genes and is highly expressed in skeletal muscle. This raises the question of whether Mll4 has a regulatory function in modulating the state transitions of MuSCs, warranting further investigation.

Methods

To assess if myofiber-expressed Mll4, a histone methyltransferase, contributes to the maintenance of MuSCs, we crossed MCK^Cre/+ or HSA^MerCreMer/+ mice

SUBMITTER: Kim YE 

PROVIDER: S-EPMC11665228 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature