Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.

ABSTRACT:

Background

In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying the association between frailty and mental disorders remain unclear.

Methods

We conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between frailty, as measured by the frailty index (FI), and ten common mental disorders. The datasets involved European ancestry individuals and included measurements of the FI (N = 175,226), schizophrenia (SCZ; N = 320,404), major depressive disorder (MDD; N = 143,265), bipolar disorder (N = 337,199), insomnia (N = 462,341), obsessive-compulsive disorder (N = 33,925), anxiety disorders (N = 463,010), autism spectrum disorder (N = 46,351), anorexia nervosa (N = 14,477), opioid

SUBMITTER: Sun W 

PROVIDER: S-EPMC11665248 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature