Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2.

ABSTRACT: T cells are involved in protective immunity against numerous viral infections. Data regarding functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID-19 are limited. To address this knowledge gap, we assessed samples for associations between SARS2 upper respiratory tract viral RNA levels and early virus-specific adaptive immune responses for 95 unvaccinated clinical trial participants with acute primary COVID-19 aged 18-86 years old, approximately half of whom were considered at high risk for progression to severe COVID-19. Functionality and magnitude of acute SARS2-specific CD4+ and CD8+ T cell responses were evaluated, in addition to antibody responses. Most individuals with acute COVID-19 developed SARS2-specific T cell responses within 6 days of COVID-1

SUBMITTER: Ramirez SI 

PROVIDER: S-EPMC11665554 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature