Gaps in the management of adrenal insufficiency in melanoma survivors: a retrospective cohort study.

ABSTRACT:

Background

Due to limited data on managing immunotherapy-induced secondary adrenal insufficiency (SAI) in melanoma survivors, this study investigated its management strategies and outcomes.

Methods

This retrospective cohort study analyzed melanoma patients treated with immune checkpoint inhibitors (ICIs) with SAI (Mel_SAI, n = 161), without SAI (Mel_CON, n = 168), and patients with pituitary adenoma-related SAI (Pit_SAI, n = 106) at our institution from January 2013 to November 2023. We compared glucocorticoid management patterns, quality of life using distress scores, and the impact of different glucocorticoid types on survival outcomes using Kaplan-Meier analysis.

Findings

Mel_SAI received significantly higher initial (median: 30 mg; IQR: 20-30 mg) and maintenance (

SUBMITTER: Lin W 

PROVIDER: S-EPMC11665661 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature