Mathematical comparison of protocols for adapting a bacteriophage to a new host.

ABSTRACT: Interest in phage therapy-the use of bacterial viruses to treat infections-has increased recently because of the rise of infections with antibiotic-resistant bacteria and the failure to develop new antibiotics to treat those infections. Phages have shown therapeutic promise in recent work, and successful treatment minimally requires giving the patient a phage that will grow on their infecting bacterium. Although nature offers a bountiful and diverse supply of phages, there have been a surprising number of patient infections that could not be treated with phages because no suitable phage was found to kill the patient's bacterium. Here, we develop computational models to analyze an alternative approach to obtaining phages with new host ranges-directed evolution via laboratory propagation of

SUBMITTER: Bull JJ 

PROVIDER: S-EPMC11665826 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature