E93 controls adult differentiation by repressing <i>broad</i> in <i>Drosophila</i>.

ABSTRACT: In Drosophila melanogaster, successful development relies on the precise coordination of both spatial and temporal regulatory axes. The temporal axis governs stage-specific identity and developmental transitions through a number of genes, collectively forming the Metamorphic Gene Network. Among these, Ecdysone inducible protein 93F (E93) serves as the critical determinant for adult specification, but its mechanism of action remains unclear. Here, we found that, rather than acting mainly as an instructive signal, E93 promotes adult differentiation through the repression of the pupal specifier broad (br). In the absence of E93, sustained high levels of Br during the pupal stage strongly represses pupal-specific enhancers that are essential for the terminal differe

SUBMITTER: Cruz J 

PROVIDER: S-EPMC11665871 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature