Modeling the within-host dynamics of <i>Plasmodium vivax</i> hypnozoite activation: An analysis of the SPf66 vaccine trial.

ABSTRACT: Plasmodium vivax parasites can lie dormant in the liver as hypnozoites, activating weeks to months after sporozoite inoculation to cause relapsing malarial illness. It is not known what biological processes govern hypnozoite activation. We use longitudinal data from the most detailed cohort study ever conducted in an area where both Plasmodium falciparum and P. vivax were endemic to fit a simple within-host mathematical model of P. vivax hypnozoite activation. 1,344 children living on the Thailand-Myanmar border were followed daily for 21 mo. There were 2,504 vivax and 1,164 falciparum malaria symptomatic episodes recorded over 1988 person-years. The model assumes that hypnozoites activate independently at a constant rate ("exponential clock model"). When this m

SUBMITTER: Mehra S 

PROVIDER: S-EPMC11665876 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature