Prednisolone pharmacokinetics in dogs with protein-losing enteropathy.

ABSTRACT:

Background

It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein-losing enteropathy (PLE).

Objective

To compare pharmacokinetics (PK) of orally administered prednisolone in dogs with PLE vs healthy controls.

Animals

Fourteen dogs with well-characterized PLE and 7 control dogs.

Methods

Prospective case-controlled study. Dogs were treated with 1 mg/kg prednisolone PO once daily for approximately 3 weeks. Venous blood samples were collected at set timepoints before and after prednisolone administration on the first (T1) and final (T2) study days. Total and non-protein bound serum prednisolone concentrations were determined using liquid chromatography tandem-mass spectrometry, and pharmacokineti

SUBMITTER: Jablonski SA 

PROVIDER: S-EPMC11665961 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature