Surveillance for TB drug resistance using routine rapid diagnostic testing data: Methodological development and application in Brazil.

ABSTRACT: Effectively responding to drug-resistant tuberculosis (TB) requires accurate and timely information on resistance levels and trends. In contexts where use of drug susceptibility testing has not been universal (i.e. not all patients are offered testing), surveillance for rifampicin-resistance-one of the core drugs in the TB treatment regimen-has relied on resource-intensive and infrequent nationally-representative prevalence surveys. The expanded availability of rapid diagnostic tests (RDTs) over the past decade has increased testing coverage in many settings. However, RDT data collected in the course of routine (but not universal) use may provide biased estimates of resistance if the subset of patients receiving RDTs is not representative of the overall cohort. Here, we developed a method

SUBMITTER: Baum SE 

PROVIDER: S-EPMC11665995 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature