Optimization of meropenem continuous infusion based on Monte Carlo simulation integrating with degradation study.

ABSTRACT:

Objective

Meropenem degradation poses a challenge to continuous infusion (CI) implementation. However, data about the impact of degradation on the probability of target attainment (PTA) of meropenem has been limited. This study evaluated the stability of meropenem brands and the consequence of in-bottle degradation on PTA in different environmental scenarios.

Method

Seven meropenem generic brands prepared at concentrations of 1 g/48mL and 2 g/48mL in saline were examined at 25, 30, and 37°C over 8 h. A linear mixed-effects model was used to estimate degradation rate constant and potential covariates. In-bottle stability data was subsequently integrated as input for a deterministic and stochastic simulation using a published population pharmacokinetic model of critical illnes

SUBMITTER: Tien NTN 

PROVIDER: S-EPMC11666027 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature