Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model.

ABSTRACT: The zebrafish (Danio rerio) is a valuable model organism for studying human biology due to its easy genetic manipulation and small size. It is optically transparent and shares genetic similarities with humans, making it ideal for studying developmental processes, diseases, and drug screening via imaging-based approaches. Solid malignant tumors often contain hypoxic areas that stimulate the release of extracellular vesicles (EVs), lipid-bound structures released by cells into the extracellular space, that facilitate short- and long-range intercellular communication and metastatization. Here we investigate the effects of EVs derived from neuroblastoma (NB), a pediatric solid tumor, on metastatic niche formation using the zebrafish as an in vivo model. Intravascular injection in zebrafish emb

SUBMITTER: Fietta A 

PROVIDER: S-EPMC11666040 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature