Exploring the mechanism of avenanthramide in the treatment of atherosclerosis based on network pharmacology and molecular docking: An observational study.

ABSTRACT: Atherosclerosis (AS) is a disease characterized by the buildup of fat and fibrous elements within the walls of arteries and is a primary factor in the occurrence of heart failure and mortality. The potential targets and mechanisms underlying the anti-atherosclerotic effects of avenanthramide (Avn) were investigated using network pharmacology, molecular docking, and molecular dynamics simulations. Target information for Avn A, B, and C was collected from the PubChem and Swiss Target Prediction databases. Potential therapeutic targets for AS were identified by mining the OMIM, DrugBank, DisGeNET, and GeneCards databases. A protein-protein interaction (PPI) network of shared targets was constructed and visualized using the STRING database and Cytoscape 3.9.1. Gene Ontology and Kyoto Encyclope

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11666176 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature