Evaluating hippocampal replay without a ground truth.

ABSTRACT: During rest and sleep, memory traces replay in the brain. The dialogue between brain regions during replay is thought to stabilize labile memory traces for long-term storage. However, because replay is an internally driven, spontaneous phenomenon, it does not have a ground truth - an external reference that can validate whether a memory has truly been replayed. Instead, replay detection is based on the similarity between the sequential neural activity comprising the replay event and the corresponding template of neural activity generated during active locomotion. If the statistical likelihood of observing such a match by chance is sufficiently low, the candidate replay event is inferred to be replaying that specific memory. However, without the ability to evaluate whether replay detection

SUBMITTER: Takigawa M 

PROVIDER: S-EPMC11666237 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature