Comparative analysis of SDC2 and SEPT9 methylation tests in the early detection of colorectal cancer: a systematic review and meta-analysis.

ABSTRACT:

Purpose

This meta-analysis aimed to evaluate the comparative diagnostic efficacy of Syndecan-2(SDC2) and Septin-9(SEPT9) in the early detection of colorectal cancer (CRC).

Methods

We searched PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to October 2024. A direct head-to-head comparator analysis were performed using the random-effects model. Subgroup analyses and corresponding meta-regressions focusing on sample source, number of patients, region, study design, and methylated detection methods were conducted. Intra-group and inter-group heterogeneity were assessed by Cochrane Q and I² statistics.

Results

Eleven articles involving 1,913 CRC patients and 2,851 healthy people were included in the meta-anal

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11666333 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature