Association of perioperative initiation of gabapentin versus pregabalin with kidney function: a target trial emulation study.

ABSTRACT:

Background

Gabapentinoids, such as gabapentin and pregabalin, are opioid substitutes commonly included in perioperative multimodal analgesia regimens. We investigated whether the initiation of gabapentin and pregabalin during the perioperative period have varying effects on the adverse renal outcomes.

Methods

This study included adult participants who received surgery in the INSPIRE database. The exposure of interest was the initiation of pregabalin or gabapentin during the perioperative period. The primary outcome was renal function decline. Secondary outcomes included incident chronic kidney disease (CKD), hospital-acquired acute kidney injury (AKI), and in-hospital mortality. We conducted a propensity score to balance the baseline characteristics. Cox proportional hazard

SUBMITTER: He Y 

PROVIDER: S-EPMC11666351 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature