Longitudinal study of cognitive function in people with HIV and toxoplasmic encephalitis or latent toxoplasma infection.

ABSTRACT:

Background

Neurocognitive impairment (NCI) may occur during and persist even after recovery from HIV-related central nervous system (CNS) co-infections such as toxoplasmic encephalitis (TE). The long-term cognitive effects of TE and latent toxoplomasmic infections (LTI) among persons with HIV (PWH) are unknown. We measured longitudinal effects on neurocognitive functioning in PWH with TE compared to LTI or no toxoplasmal infection.

Methods

PWH (n = 345) followed in two longitudinal cohort studies underwent comprehensive neurocognitive assessments and an anti- toxoplamic immunoglobulin G (IgG) assay. Participants were classified into one of three groups: TE+ ( n  = 39), LTI+ ( n  = 34), LTI- ( n  = 272). The primary outcome was change in neurocognitive function between baseli

SUBMITTER: Diaz MM 

PROVIDER: S-EPMC11666403 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature