Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity.

ABSTRACT:

Objective

Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, β cell insulin sensitivity, and glycolysis in youth with obesity.

Methods

A total of 27 youth with obesity (11 girls, BMI percentile, median [25th-75th percentiles]: 99.0 [97.9-99.0]) wore a continuous glucose monitoring device for 10 days and underwent a 3-h oral glucose tolerance test. β cell function was assessed using the oral minimal model, and liver proton density fat fraction was measured by magnetic resonance imaging.

Results

Average sensor-derived glucose and glucose standard deviation (STDEV) and coefficient of variation (CV) were associated with liver

SUBMITTER: Barbieri E 

PROVIDER: S-EPMC11666407 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature