Association of smoking with neurocognition, inflammatory and myeloid cell activation profiles in people with HIV on antiretroviral therapy.

ABSTRACT:

Objective

People with HIV (PWH) experience excess comorbidities, including neurocognitive disorders, which are linked to inflammation, particularly monocyte-macrophage activation. Smoking contributes to morbidity and mortality in well treated PWH. We investigated associations between smoking, neurocognitive function, and inflammation in PWH on antiretroviral therapy (ART).

Design

We used baseline data on cognition and inflammation from a longitudinal study of virologically suppressed PWH who do and do not smoke.

Methods

Participants completed four neurocognitive tests (seven measures), with a composite score as the primary measure. Inflammatory markers were plasma sCD14, sCD163, and CCL2/MCP-1; %CD14 + monocytes expressing CD16, CD163, and CCR2; and %CD8 + T cells co-

SUBMITTER: Yadav A 

PROVIDER: S-EPMC11666410 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature