Offline ensemble co-reactivation links memories across days.

ABSTRACT: Memories are encoded in neural ensembles during learning^1-6 and are stabilized by post-learning reactivation^7-17. Integrating recent experiences into existing memories ensures that memories contain the most recently available information, but how the brain accomplishes this critical process remains unclear. Here we show that in mice, a strong aversive experience drives offline ensemble reactivation of not only the recent aversive memory but also a neutral memory formed 2 days before, linking fear of the recent aversive memory to the previous neutral memory. Fear specifically links retrospectively, but not prospectively, to neutral memories across days. Consistent with previous studies, we find that the recent aversive memory ensemble is reactivated during the offline

SUBMITTER: Zaki Y 

PROVIDER: S-EPMC11666460 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature