Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values.

ABSTRACT:

Objectives

C-Reactive Protein (CRP) values are partly determined by variation at the CRP gene locus, but also influenced by socioeconomic position (SEP) and related lifestyle factors. As gene-by-SEP interactions have been suggested for traits associated with CRP and SEP (e.g., BMI, coronary artery disease), the aim of this study was to investigate the strength of a possible interaction between a CRP gene common variant (rs4287174) and SEP in their joint influence on CRP levels in a population-based study sample.

Methods

Single nucleotide polymorphism rs4287174 was genotyped in 4065 participants (aged 45-75 years) of the Heinz Nixdorf Recall study, a population-based prospective cohort. SEP indicators (education and income), risk factors (i.e., body mass index (BMI), total ch

SUBMITTER: Cheaib M 

PROVIDER: S-EPMC11666539 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature