Characteristics of peripheral immune response induced by large-vessel occlusion in patients with acute ischemic stroke.

ABSTRACT:

Introduction

Despite improvements in the treatment of acute ischemic stroke (AIS), some patients still suffer from functional impairments, indicating the poor understanding of pathophysiologic process of AIS. Inflammation plays an important role in the pathophysiology of AIS. The purpose of the study was to investigate the peripheral inflammation in different subtypes of AIS.

Methods

Here, retrospective data from AIS with large vessel occlusion (LVO) and small vessel occlusion (SVO), and healthy controls, were initially analyzed. Then, flow cytometry was performed to evaluate the levels of peripheral naïve and memory T-cells. Finally, we characterized the T cell receptors (TCR) repertoire using high-throughput sequencing.

Results

Elevated levels of leukocytes, neutrop

SUBMITTER: Ma L 

PROVIDER: S-EPMC11666556 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature