Individualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.

ABSTRACT: Accumulating studies have highlighted the links between stress-related networks and the HPA axis for emotion regulation and proved the mapping associations between altered structural and functional networks (called SC-FC coupling) in depression. However, the signatures of SC-FC coupling in subthreshold depression (StD) individuals and their relationships with HPA axis reactivity, as well as the predictive power of these combinations for discriminating StD, remain unclear. This cross-sectional study enrolled 160 adults, including 117 StD and 43 healthy controls (HC). The propensity score matching method was applied for match-pair analysis between StD and HC. Herein, we measured depression level, cortisol level, and brain imaging outcomes. The functional MRI and diffusion tensor imaging meth

SUBMITTER: He Y 

PROVIDER: S-EPMC11666575 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature