Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells.

ABSTRACT: The application of upconversion nanoparticles (UCNPs) for cell and tissue analysis requires a comprehensive understanding of their interactions with biological entities to prevent toxicity or harmful effects. Whereas most studies focus on cancer cells, this work addresses non-cancerous cells with their regular in vitro physiology. Since it is generally accepted that surface chemistry largely determines biocompatibility in general and uptake of nanomaterials in particular, two bilayer surface coatings with different surface shielding properties have been studied: (i) a phospholipid bilayer membrane (PLM) and (ii) an amphiphilic polymer (AP). Both surface modifications are applied to (12-33) nm core-shell UCNPs NaYF₄(Yb, Er)@NaYF₄, ensuring colloidal stability in biolog

SUBMITTER: Markl S 

PROVIDER: S-EPMC11666596 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature