Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults.

ABSTRACT:

Background

Elevated cefepime blood concentrations can cause neurotoxicity in adults. The consequences of elevated cefepime concentrations among pediatric patients are unknown. Future exploration of such effects requires first identifying patients at risk for elevated cefepime exposure. We investigated the role of acute kidney injury as a risk factor for increased cefepime concentrations in critically ill children.

Methods

This was a retrospective analysis at a single pediatric intensive care unit. Analyzed patients received at least 24 h of cefepime and had at least two opportunistic samples collected for total cefepime concentration measurement. Individual pharmacokinetic (PK) profiles during treatment courses were reconstructed using Bayesian estimation with an established

SUBMITTER: Pavia K 

PROVIDER: S-EPMC11666613 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature