Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis.

ABSTRACT: Aneuploidy in eggs is a leading cause of miscarriages or viable developmental syndromes. Aneuploidy rates differ between individual chromosomes. For instance, chromosome 21 frequently missegregates, resulting in Down Syndrome. What causes chromosome-specific aneuploidy in meiosis is unclear. Chromosome 21 belongs to the class of acrocentric chromosomes, whose centromeres are located close to the chromosome end, resulting in one long and one short chromosome arm. We demonstrate that acrocentric chromosomes are generally more often aneuploid than metacentric chromosomes in porcine eggs. Kinetochores of acrocentric chromosomes are often partially covered by the short chromosome arm during meiosis I in human and porcine oocytes and orient less efficiently toward the spindle poles. These partia

SUBMITTER: Bellou E 

PROVIDER: S-EPMC11666783 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature