No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study.

ABSTRACT: Recently, there has been a debate regarding the association between polycystic ovary syndrome (PCOS) and pancreatic cancer (PC). In order to examine the causal relationship between PCOS and PC, we conducted a Mendelian randomization study, which utilized 12 single nucleotide polymorphisms (SNPs) identified from a genome-wide association study (GWAS) meta-analysis that included 10,074 PCOS cases and 103,164 controls of European ancestry as instrumental variables (IVs). The outcome data were obtained from the FinnGen database (including 605 cases and 218,187 controls). We demonstrate that genetically predicted PCOS is not causally associated with PC risk in Europeans (odds ratio = 0.99, 95% confidence interval (CI) = 0.72-1.36, p > 0.05). Sensitivity analysis showed horizontal pleiotr

SUBMITTER: Gao X 

PROVIDER: S-EPMC11666843 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature