Secondary anti-viral prophylaxis in solid organ transplant recipients for the prevention of cytomegalovirus relapse: A systematic review and meta-analysis.

ABSTRACT:

Background

Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ transplant recipients (SOTRs). Secondary prophylaxis (SP) is not routinely recommended by guidelines on the management of CMV in SOTR but may be considered in certain higher-risk situations.

Methods

A comprehensive search of English language publications up to September 2023 was performed. The primary outcome was CMV relapse, defined as the recurrence of DNAemia or disease. Secondary outcomes included graft loss, mortality, and hematological toxicity. Meta-analysis used the random-effects model. The study protocol is registered in PROSPERO (no. CRD42022357028).

Results

Six retrospective comparative studies were included. A total of 520/727 (72%) of SOTR received SP with v

SUBMITTER: Moynan D 

PROVIDER: S-EPMC11666880 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature