Coupling of mitochondrial state with active zone plasticity in early brain aging.

ABSTRACT: Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic active zone proteins ("PreScale") are considered a dynamic, resilience-enhancing form of plasticity in the process of early, still reversible aging of the Drosophila brain. Aging, however, triggers significant changes not only of synapses but also mitochondria. While the two organelles are spaced in close proximity, likely reflecting a direct functional coupling in regard to ATP and Ca²⁺ homeostasis, the exact modes of coupling in the aging process remain to understood. We here show that genetic manipulations of mitochondrial functional status, wh

SUBMITTER: Fei L 

PROVIDER: S-EPMC11666929 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature