Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease.

ABSTRACT:

Background

A dual-syndrome hypothesis, which states the cognitive impairments in Parkinson's disease (PD) are attributable to frontostriatal dopaminergic dysregulation and cortical disturbance-each associated with attention/executive and memory/visuospatial dysfunction, respectively-has been widely accepted. This multisystem contribution also underlies highly heterogeneous progression rate to dementia.

Methods

Nondemented PD patients who underwent [¹²³I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([¹²³I]FP-CIT) SPECT and neuropsychological examinations were enrolled. Patients who agreed to participate and age- and sex-matched healthy controls (HCs) also underwent 7-T MRI. Patients were classified as cognitively normal (PD-CN) or mild c

SUBMITTER: Yoshimura K 

PROVIDER: S-EPMC11666957 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature