A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma.

ABSTRACT:

Background

Asthma is a global chronic respiratory disease with complex pathogenesis. While current therapies offer some relief, they often fall short in effectively managing symptoms and preventing exacerbations for numerous patients. Thus, understanding its mechanisms and discovering new drug targets remains a pressing need for better treatment.

Methods

Using the GEO dataset, we screened differentially expressed genes (DEGs) in asthma patients' blood. Employing Summary Data-based Mendelian Randomization (SMR) and Two-Sample Mendelian Randomization (TSMR), we pinpointed asthma causal genes, causal DNA methylation sites, and methylation sites affecting gene expression, cross validated with at least 2 large-scale GWAS from each source. We utilized colocalization for genetic as

SUBMITTER: Wang J 

PROVIDER: S-EPMC11667005 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature