Triphenyl-Modified Mixed-Mode Stationary Phases With and Without Embedded Ion-Exchange Sites for High-Performance Liquid Chromatography.

ABSTRACT: The present work reports on the preparation, characterization, and evaluation of a set of novel triphenyl-modified silica-based stationary phases without and with embedded ion-exchange sites for mixed-mode liquid chromatography. The three synthesized triphenyl phases differed in additionally incorporated ion-exchange sites. In one embodiment, allyltriphenylsilane was bonded to thiol-modified silica by thiol-ene click reaction, leading to particles with no ion-exchange sites. A second stationary phase was obtained by thiol-yne click reaction of thiol silica with 2-propinyl-triphenylphosphonium bromide, yielding a strong anion-exchanger (SAX). A third stationary phase was obtained from this SAX phase by the oxidation of residual thiols to sulfonic acid moieties, leading to a zwitterionic sur

SUBMITTER: Wolter M 

PROVIDER: S-EPMC11667146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature