ScRNA-Seq Analysis of Tongue Tissues in Chronic Hyperplastic Candidiasis.

ABSTRACT: Chronic hyperplastic candidiasis (CHC) is a rare but severe subtype of oral candidiasis distinguished by its potential malignant transformation and suboptimal response to antifungal therapies. However, the cells and mechanisms that play key roles in this process remain unclear. Therefore, we performed the first single-cell RNA sequencing (scRNA-seq) analysis of CHC-affected tongue tissues to reveal the microenvironmental changes and immunological etiology of CHC. First, the features of CHC lesions manifesting as thickening and hardening nodular lesions, including their pathological and microbiological characteristics, were elucidated. Then, a comprehensive cellular atlas and distinct immune landscape in CHC compared with healthy tissues were characterized using scRNA-seq, highlighting sign

SUBMITTER: Zhou P 

PROVIDER: S-EPMC11667191 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature