<i>SPRR1A</i> is a potential therapeutic target for osteosarcoma: <i>in vitro</i> and <i>in vivo</i> evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

ABSTRACT: Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected wit

SUBMITTER: Miyamoto T 

PROVIDER: S-EPMC11667212 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature