Impact of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal outcomes: a pilot randomised clinical trial.

ABSTRACT:

Objective

To investigate the impact of dexmedetomidine-ropivacaine combination versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal and maternal outcomes and test the feasibility of a future large, randomised trial.

Design

A randomised, double-blind, pilot clinical trial from 16 March 2023 to 15 June 2023.

Setting

A tertiary-care hospital in Beijing, China.

Participants

200 women aged≥18 years who had full-term single pregnancy and were scheduled for vaginal delivery with epidural analgesia.

Interventions

Eligible participants were randomly assigned in a 1:1 ratio to receive self-controlled epidural labour analgesia using ropivacaine supplemented with either dexmedetomidine (0.45 µg/mL for induction and 0.36 µg/mL for maint

SUBMITTER: Jin KX 

PROVIDER: S-EPMC11667271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature