Real-world analysis of acamprosate use in patients with cirrhosis and alcohol-associated hepatitis.

ABSTRACT:

Objective

Preventing return to alcohol is of critical importance for patients with alcohol-related cirrhosis and/or alcohol-associated hepatitis. Acamprosate is a widely used treatment for alcohol use disorder (AUD). We assessed the impact of acamprosate prescription in patients with advanced liver disease on abstinence rates and clinical outcomes.

Methods

This was a retrospective case-control study. We reviewed data on all patients admitted to a large tertiary centre in the UK with alcohol-related cirrhosis and/or alcohol-associated hepatitis. We used propensity risk score matching to match patients prescribed acamprosate to controls. The primary outcome was repeat hospitalisation.

Results

There were 451 patients who met the inclusion criteria of whom 55 patients wer

SUBMITTER: Oldroyd C 

PROVIDER: S-EPMC11667394 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature