Efficacy of opioid combination versus single opioid for adult cancer pain: a protocol for systematic review and meta-analysis.

ABSTRACT:

Introduction

Chronic pain is one of the most common and serious symptoms of cancer. Despite the limitations of dose titration using only one type of opioid, the effects of opioid combinations are poorly understood.

Methods and analysis

This study will be conducted in accordance with the Cochrane Handbook of Systematic Reviews of Interventions 6.3. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Web of Science databases from their inception to June 2023. This review will consider all clinical trials involving patients aged ≥18 years who received opioids for chronic cancer pain. Two reviewers will independ

SUBMITTER: Maeng CH 

PROVIDER: S-EPMC11667427 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature