Peripheral risk factors and their role in biomarker-based screening for dementia in the community.

ABSTRACT:

Introduction

Peripheral risk factors (PRFs) may correlate with dementia plasma biomarkers, potentially reflecting peripheral rather than brain health. This study explores the associations between PRFs and plasma biomarkers glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and total-tau, and their role in predicting future dementia.

Methods

Data from the Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2015) included 4353 participants mean age of 76.6 years. A subsample of 910 participants tested their association with PRFs and plasma biomarkers' predictive performance. Sociodemographic, clinical, laboratory, sensory, and lifestyle variables (n = 305) were grouped into 34 clusters.

Results

Besides age and estimated glomerular filtration

SUBMITTER: Hu YH 

PROVIDER: S-EPMC11667489 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature