Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.

ABSTRACT:

Introduction

Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities.

Methods

We analyzed the association of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) and modified CAIDE (mCAIDE) scores with dementia risk using logistic regression models stratified by race/ethnicity in National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Neuroimaging Initiative (ADNI), and assessed their interaction with apolipoprotein E (APOE).

Results

Higher CAIDE scores were associated with an increased risk of dementia in Asian, Latinx, and NLW participants but not in Black part

SUBMITTER: Andrews SJ 

PROVIDER: S-EPMC11667490 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature