Latent change-on-change between amyloid accumulation and cognitive decline.

ABSTRACT:

Introduction

While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored.

Methods

A series of bivariate latent change score models (LCSM) examined the relationship between changes in ¹¹C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS).

Results

Aβ accumulation was associated with subsequent cognitive decline beyond the eff

SUBMITTER: Klinger HM 

PROVIDER: S-EPMC11667500 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature