Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease.

ABSTRACT:

Introduction

Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex (RSC) as an early site of hypometabolism in MCI which seems to be predictive of later transition to Alzheimer's disease (AD).

Methods

We examined N = 399 MCI subjects with baseline ¹⁸F-fluorodeoxyglucose positron emission tomography. Subjects were classified based on whether their diagnosis converted from MCI to AD.

Results

Whole-brain metabolism was decreased in converters (MCI-AD). This effect was more prominent at the RSC, where MCI-AD subjects showed even greater hypometabolism. Observations of RSC hypometabolism and

SUBMITTER: Terstege DJ 

PROVIDER: S-EPMC11667509 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature