Midlife and late-life environmental exposures on dementia risk in the Wisconsin Longitudinal Study: The modifying effects of ApoE.

ABSTRACT:

Introduction

Late-life air pollution exposure is associated with an increased risk for dementia, with this effect exacerbated among apolipoprotein E-4 (ApoE-4) carriers. However, whether midlife occupational exposures likewise influence dementia outcomes, and varies as a function of ApoE-4 status is unknown.

Methods

Using data from 3814 participants in the Wisconsin Longitudinal Study (WLS), we employed weighted logistic regression to evaluate associations between midlife occupational respiratory exposures and late-life air pollution on all-cause dementia risk, stratified by ApoE-4 status.

Results

Midlife occupational exposure was associated with increased odds of all-cause dementia preferentially among ApoE-4 noncarriers (odds ratio [OR] = 1.59, p = 0.01), whereas hi

SUBMITTER: Williams VJ 

PROVIDER: S-EPMC11667516 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature