SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes.

ABSTRACT:

Introduction

We investigated hippocampal synaptic density using synaptic vesicle 2A positron emission tomography (PET), and its association with amyloid beta (Aβ) and cognitive performance in healthy apolipoprotein E (APOE) ε4 carriers.

Methods

Synaptic density was assessed in 46 individuals (APOE ε4/ε4 n = 14; APOE ε3/ε4 n = 16; APOE ε3/ε3 n = 16) with [¹¹C]UCB-J-PET standardized uptake value ratios (SUVRs), by using the centrum semiovale as a reference region. Differences in hippocampal [¹¹C]UCB-J SUVRs were analyzed with analysis of variance (ANOVA) and linear models. Associations among [¹¹C]UCB-J SUVR, Aβ, hippocampal volume, and cognitive variables were analyzed with Spearman correlation.

Results

Hippocampal synaptic density was d

SUBMITTER: Snellman A 

PROVIDER: S-EPMC11667521 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature