Cerebral perfusion and amyloidosis in the oldest-old.

ABSTRACT:

Introduction

In a nested case-control study, we examined how cerebral perfusion relates to cognitive status and amyloid in the oldest-old (i.e., 90 years of age and older).

Methods

Study participants included 113 dementia-free older adults (76 cognitively normal [CN]; 37 cognitively impaired, no dementia [CIND]) from the 90+ Study (mean age = 92.9, SD = 2.4). We quantified regional perfusion from arterial spin labeling-MRI (magnetic resonance imaging) and amyloid deposition from florbetapir-positron emission tomography (PET) in a region comprising the posterior cingulate and precuneus (PCC+PCu), and additionally quantified perfusion in other regions important for cognitive decline (medial temporal lobe, inferior parietal lobe, and orbitofrontal cortex).

Results

Partic

SUBMITTER: Dutt S 

PROVIDER: S-EPMC11667522 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature