Microscopy assessment of a fluorescence [¹⁸F] flortaucipir analog (T726) shows neuropathological overlap with 3R and 4R tau lesions.

ABSTRACT:

Background

[¹⁸F] flortaucipir (FTP) binding to paired helical filament (PHF) tau in Alzheimer's disease (AD) is well accepted. Binding to 3R and 4R tau in frontotemporal lobar degeneration (FTLD) is controversial. We aimed to investigate whether an FTP fluorescent analog (T726) can help shed light on this controversy.

Method

We assessed T726 binding to amyloid beta (Aβ) and different tau isoforms in nine subjects (one control, three with Alzheimer's disease [AD], and five with FTLD) with different 3R and 4R tauopathies using fluorescence confocal microscopy.

Results

T726 did not colocalize with Aβ but showed significant co-localization with PHF tau in AD. We also observed some, albeit limited, co-localization of T726 with 3R and 4R tau lesions in FTLD.

D

SUBMITTER: Gatto RG 

PROVIDER: S-EPMC11667531 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature